The Role of Obesity in Breast Cancer Pathogenesis

Research has shown that obesity increases the risk for type 2 diabetes mellitus (Type DM) by promoting insulin resistance, serum estrogen levels upregulation of aromatase, and promotes release reactive oxygen species (ROS) macrophages. Increased circulating glucose been to activate mammalian target rapamycin (mTOR), a significant signaling pathway in breast cancer pathogenesis. Estrogen plays an instrumental role estrogen-receptor-positive cancers. The ROS warrants continued investigation, relation both pathogenesis treatment cancer. We aim review novel therapies mediating obesity-associated development. explore association between body mass index (BMI) incidence mechanisms which oxidative stress modulates discuss glutathione, ubiquitous antioxidant, therapy. Lastly, we targeting mTOR signaling, leptin blood sugar reduction, immunotherapy targets.